# NIH Reporter #1F31CA301909-01A1

Uncovering the roles of symmetric dimethylation of arginine on ZNF326

**Recipient:** Virginia Polytechnic Institute and State University

**Award Amount:** $45,528.00
**Ceiling:** $45,528.00

**Awarded:** May 14, 2026

**Identifier:** 1F31CA301909-01A1

Research project funded by the National Cancer Institute to study the enzyme PRMT5 and its role in cancer, focusing on molecular mechanisms and potential therapeutic targets.

### Description

The project aims to understand the roles and binding mechanisms of the enzyme PRMT5, a therapeutic target in certain cancers. It focuses on the methylation of substrates like ZNF326 and their role in pancreatic ductal adenocarcinoma. The study involves co-immunoprecipitation mass spectrometry, mutant analysis, and RNA sequencing to elucidate PRMT5's function and interactions, potentially leading to targeted cancer therapies.

[View original record](https://reporter.nih.gov/search/IgE1H2ioLUOz0qmA4MDg0Q/project-details/11318600)