Award
NIH Reporter #5R01AI158830-05
Investigating Immune-Microbiome Interactions During Treatment of Clostridioides difficile with Fecal Microbiome Transplantation
Recipient
University of Pennsylvania
Award Amount
$468,900.00
Ceiling
$468,900.00
Awarded
February 13, 2025
Identifier
5R01AI158830-05
NIH-funded research at the University of Pennsylvania studying immune and microbiome mechanisms that may improve fecal microbiome transplantation treatment for Clostridioides difficile infection.
Description
The project investigates how the immune system interacts with fecal microbiome transplantation (FMT) to support resolution of Clostridioides difficile infection. It examines the role of regulatory T cells and inflammatory mediators in FMT engraftment and infection resolution, and profiles immune cells in patients before and after FMT.