# NIH Reporter #5R01AI158830-05

Investigating Immune-Microbiome Interactions During Treatment of Clostridioides difficile with Fecal Microbiome Transplantation

**Recipient:** University of Pennsylvania

**Award Amount:** $468,900.00
**Ceiling:** $468,900.00

**Awarded:** February 13, 2025

**Identifier:** 5R01AI158830-05

NIH-funded research at the University of Pennsylvania studying immune and microbiome mechanisms that may improve fecal microbiome transplantation treatment for Clostridioides difficile infection.

### Description

The project investigates how the immune system interacts with fecal microbiome transplantation (FMT) to support resolution of Clostridioides difficile infection. It examines the role of regulatory T cells and inflammatory mediators in FMT engraftment and infection resolution, and profiles immune cells in patients before and after FMT.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11006338)