Award
NIH Reporter #7K01DK140610-03
Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells
Recipient
North Carolina State University Raleigh
Award Amount
$108,362.00
Ceiling
$108,362.00
Awarded
August 04, 2026
Identifier
7K01DK140610-03
A research award to study transcriptional regulation of mitochondrial metabolism and inflammatory gene expression in intestinal stem cells, with the goal of improving understanding of intestinal homeostasis and disease mechanisms.
Description
The project investigates how mitochondrial metabolism affects intestinal stem cell activity, including how SOX9 regulates mitochondrial activity and pro-inflammatory genes in human intestinal stem cells and mouse intestine. It aims to identify transcription factors and downstream targets involved in intestinal homeostasis and inflammatory bowel disease.