# NIH Reporter #7K01DK140610-03

Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells

**Recipient:** North Carolina State University Raleigh

**Award Amount:** $108,362.00
**Ceiling:** $108,362.00

**Awarded:** August 04, 2026

**Identifier:** 7K01DK140610-03

A research award to study transcriptional regulation of mitochondrial metabolism and inflammatory gene expression in intestinal stem cells, with the goal of improving understanding of intestinal homeostasis and disease mechanisms.

### Description

The project investigates how mitochondrial metabolism affects intestinal stem cell activity, including how SOX9 regulates mitochondrial activity and pro-inflammatory genes in human intestinal stem cells and mouse intestine. It aims to identify transcription factors and downstream targets involved in intestinal homeostasis and inflammatory bowel disease.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11582689)