Award
NIH Reporter #5F32AI186538-02
Role of Intestinal Epithelial Cells in Controlling Local and Systemic Yersinia Infection through IL-1 Signaling
Recipient
University of Pennsylvania
Award Amount
$59,716.00
Ceiling
$59,716.00
Awarded
August 12, 2026
Identifier
5F32AI186538-02
The research examines how IL-1 signaling in intestinal epithelial cells supports neutrophil recruitment and antimicrobial defenses that contain intestinal Yersinia infection and prevent dissemination to systemic tissues.
Description
This project investigates how IL-1 signaling in intestinal epithelial cells regulates immune responses to control Yersinia pseudotuberculosis in the gut and limit its systemic spread.