# NIH Reporter #5F32AI186538-02

Role of Intestinal Epithelial Cells in Controlling Local and Systemic Yersinia Infection through IL-1 Signaling

**Recipient:** University of Pennsylvania

**Award Amount:** $59,716.00
**Ceiling:** $59,716.00

**Awarded:** August 12, 2026

**Identifier:** 5F32AI186538-02

The research examines how IL-1 signaling in intestinal epithelial cells supports neutrophil recruitment and antimicrobial defenses that contain intestinal Yersinia infection and prevent dissemination to systemic tissues.

### Description

This project investigates how IL-1 signaling in intestinal epithelial cells regulates immune responses to control Yersinia pseudotuberculosis in the gut and limit its systemic spread.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11408404)