# Simpler Grants.gov #RFA-AI-28-005

NIH research funding to continue the Immune Tolerance Network and develop immune-tolerance therapies

**Buyer:** National Institutes of Health
**Posted:** October 20, 2026
**Respond By:** January 29, 2027
**Identifier:** RFA-AI-28-005
**NAICS:** 541715

The National Institutes of Health is seeking applications to continue the Immune Tolerance Network and advance therapies for immune-mediated disorders.
- **Government buyer:** National Institutes of Health (NIH), through its Division of Allergy, Immunology and Transplantation (DAIT).
- **Opportunity type:** Research funding through a cooperative agreement, not a product procurement.
- **Program:** Continue the Immune Tolerance Network (ITN), developing tolerogenic therapies for allergic diseases and asthma, autoimmune diseases, and immune-mediated consequences of transplantation.
- **Core work:** Design and conduct clinical trials, share trial results, and perform integrated mechanistic studies.
- **Funding and award:** $21,986,000 in program funding; one award is anticipated.
- **OEMs and vendors:** No manufacturers, vendors, or resellers are identified.
- **Products and quantities:** No products, part numbers, or product quantities are specified.

### Description

This notice supports applications to continue the Immune Tolerance Network (ITN), whose primary objective is to develop tolerogenic therapies for immune-mediated disorders. The work covers allergic diseases and asthma, autoimmune diseases, and immune-mediated consequences of transplantation. ITN core functions include designing, conducting, and sharing clinical trial results and performing integrated mechanistic studies. Program funding is $21,986,000, with one expected award.

[View original listing](https://simpler.grants.gov/opportunity/362946)