# SAM #ARPA-H-SN-26-164

ARPA-H SURPASS program seeks teams to develop and validate adaptive clinical-trial platforms

**Buyer:** ARPA-H
**Posted:** September 30, 2026
**Respond By:** October 13, 2026
**Identifier:** ARPA-H-SOL-26-164
**NAICS:** 541714, 541715, 325414

ARPA-H’s Proactive Health Office is seeking teams to develop and clinically validate SURPASS adaptive platform trials for a single disease area.
- **Government buyer:** Advanced Research Projects Agency for Health (ARPA-H), within the National Institutes of Health (NIH), Department of Health and Human Services (HHS); sub-agency: Proactive Health Office (PHO).
- **Program:** Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS), solicitation ARPA-H-SOL-26-164. Multiple awards are anticipated.
- **Requested work:** One integrated Core Platform Team will develop and validate a persistent adaptive platform trial for one disease area, combining a phaseless design and simulation engine, continuous inference and adaptation-validity capabilities, and AI-enabled clinical operations.
- **Team and trial requirements:** Propose at least three drug or biologic intervention arms, including at least two unapproved interventions and one with no prior human data; include at least two for-profit sponsors, including a startup or small company; and build a network of at least six clinical sites. The first site must open to enrollment by program Year 2.
- **Performance:** Five years total, comprising a 24-month platform and capability buildout stage and a 36-month validation and deployment stage. The platform is intended to remain economically sustainable for approximately 10 years after program funding ends.
- **Products and manufacturers:** No specific products, part numbers, quantities of equipment, OEMs, or commercial vendors are identified. The requested effort is an integrated research and clinical-trial platform service.
- **Award structure:** ARPA-H anticipates multiple awards. The notice also describes an informational webinar and Proposers’ Day.

### Description

<p>The Advanced Research Projects Agency for Health (ARPA-H) posts this Special Notice in support of its Simulation-augmented, Real-time Platform Adaptive Seamless Trials (SURPASS)&nbsp;Program.</p>

<p>Interested parties are invited to review the attached Notice related to an informational webinar on 15 OCT 2026 and a 2-day Proposers&rsquo; Day on 6 and 9 NOV 2026 in support of SURPASS. &nbsp;</p>

<p>For more information related to the SURPASS opportunity, see solicitation ARPA-H-SOL-26-164.</p>

<p>All questions related to SURPASS should be submitted to SURPASS@ARPA-H.GOV.</p>
<br/><br/><br/><strong>Additional Links:</strong><br/><a href='https://solutions.arpa-h.gov/events' target='_blank'>Register for SURPASS Events</a><br/><a href='https://arpa-h.gov/explore-funding/programs/surpass' target='_blank'>SURPASS Program Page</a><br/><a href='https://solutions.arpa-h.gov/login?url=teaming' target='_blank'>Submit a Teaming Profile</a>

[View original listing](https://sam.gov/opp/11128fed4f044b68a9185dada11c90d9/view)