# NIH Reporter #1K99NS150641-01

Macrophage remodeling of brain extracellular matrix in Krabbe disease

**Recipient:** University of Pennsylvania

**Award Amount:** $128,925.00
**Ceiling:** $128,925.00

**Awarded:** August 07, 2026

**Identifier:** 1K99NS150641-01

A K99/R00 research award to study how macrophages and microglia reshape brain extracellular matrix and tissue mechanics in Krabbe disease.

### Description

NIH research project examining how macrophages remodel brain extracellular matrix and alter tissue mechanics in Krabbe disease, a genetic pediatric leukodystrophy. The project investigates microglial fibronectin and aims to identify mechanisms that could support recovery.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11437091)