Award
National Institute of Dental and Craniofacial Research 5F30DE033234-03
Binding specificity and transcriptional regulation of antigen I/II adhesins in Streptococcus gordonii
Recipient
University of Minnesota
Award Amount
$55,338.00
Ceiling
$55,338.00
Awarded
July 28, 2025
Identifier
5F30DE033234-03
Research project funded by the National Institute of Dental and Craniofacial Research to study the binding specificity and transcriptional regulation of AgI/II adhesins in Streptococcus gordonii, which are important for biofilm formation and oral health.
Description
This project investigates the role of antigen type I/II (AgI/II) adhesins in surface attachment and biofilm formation of Streptococcus gordonii, aiming to identify conserved mechanisms that may be targeted for manipulation of Streptococci-containing biofilms. The study focuses on bacterial biofilm formation, adhesin proteins, and regulation mechanisms, with potential therapeutic implications.