Award
NIH Reporter #4R37CA248478-06
Proteomic determinants of response to checkpoint blockade in malignant pleural mesothelioma
Recipient
Not Specified
Award Amount
$407,412.00
Ceiling
$407,412.00
Awarded
January 30, 2026
Identifier
4R37CA248478-06
Research project to identify proteomic markers predicting response to checkpoint blockade therapy in malignant pleural mesothelioma using advanced analysis techniques.
Description
This project aims to identify proteomic determinants of response to checkpoint blockade therapy in malignant pleural mesothelioma (MPM). The research involves high-dimensional single cell analysis platforms, immunoproteomics, and mass spectrometry to evaluate neoantigen presence and immune response markers. The goal is to develop predictive scores and biomarkers to improve treatment strategies and response prediction.