Award
California Institute of Technology 11166119
Structural Investigation of the Central Components of the CD4+ T Cell Immunological Synapse
Recipient
California Institute of Technology
Award Amount
$54,538.00
Ceiling
$54,538.00
Awarded
July 08, 2025
Identifier
11166119
Award for structural investigation of CD4+ T cell immunological synapse using advanced microscopy techniques to inform disease treatment strategies.
Description
The project involves cryo-electron microscopy and cryo-electron tomography to study the immunological synapse, focusing on structural changes induced by binding of TCR-CD3 and CD4 to pMHCII. The project aims to inform future strategies for modulating T cell activation for disease treatment.