Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD106285-05
Pathological reprogramming of the m6A epitranscriptome in uterine fibroids
Recipient
University of Texas Health Science Center
Award Amount
$647,762.00
Ceiling
$647,762.00
Awarded
April 24, 2025
Identifier
5R01HD106285-05
Research grant for studying uterine fibroids focusing on epitranscriptomic reprogramming and potential epigenetic therapies.
Description
This project proposes a novel etiologic basis for uterine fibroid development through pathological reprogramming of the myometrial epitranscriptome and offers proof of concept for therapeutic intervention using epigenetic inhibitors of tumorigenic enhancer activity driven by m6A-chromatin crosstalk. The study aims to establish the basis of epitranscriptomic reprogramming in uterine fibroids, delineate the role of METTL3-dependent RNA methylation, elucidate its impact on gene expression, and evaluate the therapeutic potential of BRD inhibitors in a preclinical mouse model.