Award
National Institute of General Medical Sciences 1R15GM152942-01
Regulation of Cadherins by MLK3
Recipient
University of Toledo, Toledo, OH, United States
Award Amount
$451,500.00
Ceiling
$451,500.00
Awarded
September 22, 2023
Identifier
1R15GM152942-01
This NIH grant project investigates the role of MLK3 in regulating cadherins affecting cell adhesion and migration in ovarian epithelial cells, with implications for cancer research.
Description
The protein kinase, MLK3, activates MAPK signaling pathways to control biological processes. The studies aim to elucidate MLK3's role in regulating cell junction proteins E-cadherin and N-cadherin, and how this regulation affects ovarian epithelial cell-cell adhesion, tissue morphogenesis, development, cell migration, and cancer invasion.