# NIH Reporter #5R01ES036931-02

Understanding the Origins of the Mutational Landscape in Cancer

**Recipient:** University of Arkansas for Medical Sciences

**Award Amount:** $719,050.00
**Ceiling:** $719,050.00

**Awarded:** January 13, 2026

**Identifier:** 5R01ES036931-02

The University of Arkansas for Medical Sciences received NIH funding to study the origins of cancer-associated mutations, including the contributions of environmental exposures and endogenous processes.

### Description

Research project investigating how environmental mutagens and endogenous processes contribute to DNA lesions and mutational signatures in cancer. The project studies 1,2,3-Trichloropropane, bromochloroacetic acid, and furan using DNA adductomics, Nanopore sequencing, and duplex sequencing.

[View original record](https://reporter.nih.gov/search/47CiHD0bJ0u2LtDABS0zbg/project-details/11291278)