NIH Reporter #1F31AI200285-01

Defining host and Clostridioides difficile responses to metal and oxidative stress during inflammation.

Research project to study how Clostridioides difficile overcomes metal limitation and oxidative stress during infection, using biochemical and in vivo methods.

Description

This project aims to identify how C. difficile uses metal transport proteins to overcome metal limitation and oxidative stress during inflammation and how the host employs oxidative damage to mitigate infection. The study involves biochemical characterization of proteins, bacterial growth assessment, and in vivo murine infection models to understand pathogenicity.

View original record