Award
NIH Reporter #1R15HL188996-01
Profiling LNP and Blood Elements Interactions
Recipient
University of New Haven, West Haven, CT, United States
Award Amount
$496,520.00
Ceiling
$496,520.00
Awarded
August 11, 2026
Identifier
1R15HL188996-01
This NIH R15 grant supports research to develop predictive models of lipid nanoparticle interactions with blood elements, enhancing nanomedicine design and therapeutic safety. It also provides research training for undergraduate and graduate students.
Description
The project aims to improve the safety and efficacy of nanoparticle-based therapeutics by understanding how lipid nanoparticle (LNP) formulation properties influence interactions with blood cells and proteins. It will develop predictive models for nanoparticle-blood interactions, advancing drug delivery for cardiovascular, oncologic, and inflammatory diseases. The research involves formulating diverse lipid-based nanoparticles, quantifying their interactions in a custom-designed blood flow loop, and developing machine learning models to predict blood-binding profiles.