Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 3F31HD116488-02S1
Investigating how maternal metabolic dysfunction impacts mammalian gastrulation
Recipient
Yale University, New Haven, CT, United States
Award Amount
$3,000.00
Ceiling
$3,000.00
Awarded
March 25, 2026
Identifier
3F31HD116488-02S1
The award supports research investigating how maternal metabolic dysfunction, particularly the accumulation of 2-HG due to a mutation in IDH2, affects mammalian gastrulation and embryonic development, with the goal of identifying mechanisms and therapeutic targets to improve reproductive success.
Description
This project aims to understand the impact of maternal metabolic dysfunction on embryonic development, specifically gastrulation, and to identify potential therapeutic targets. It focuses on the role of maternal 2-hydroxyglutarate (2-HG) accumulation caused by a gain-of-function mutation IDH2R140Q and its effects on primary germ layer formation, mitochondrial activity, cell death, and embryonic epigenetic landscape.