National Institute of Allergy and Infectious Diseases 5R01AI174599-04

Optimization of Atypical Antimycobacterial Carbapenem Antibiotics

This NIH-funded project aims to develop new orally bioavailable atypical carbapenem antibiotics targeting mycobacterial infections, including tuberculosis and nontuberculous mycobacteria, by designing and synthesizing structurally modified compounds with enhanced potency and stability.

Description

The project involves the design, synthesis, and evaluation of new antibiotics to treat infections caused by mycobacterial pathogens, including Mycobacterium tuberculosis and nontuberculous mycobacteria such as Mycobacterium abscessus. The goal is to develop an orally bioavailable drug candidate with improved specificity for mycobacteria. The project includes synthesis of atypical carbapenem antibiotics with structural modifications, demonstrating superior potency and stability against resistant strains. The project is guided by a team with expertise in synthesis, microbiology, biochemistry, and structural biology. The project is funded under NIH grant PA-20-185.

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