Award
National Institute of Neurological Disorders and Stroke 5U01NS123252-04
Antiglutamatergic Therapy to Protect the Brain Against Nerve Agents
Recipient
HENRY M. JACKSON FDN FOR THE ADV MIL/MED
Award Amount
$721,888.00
Ceiling
$721,888.00
Awarded
August 04, 2025
Identifier
5U01NS123252-04
Research grant awarded to study antiglutamatergic therapy for neuroprotection against nerve agents in rats, focusing on efficacy and prevention of neurological damage.
Description
The project focuses on testing antiglutamatergic therapy in rats exposed to soman, a nerve agent, to evaluate neuroprotection and efficacy compared to existing treatments like midazolam. The research involves adult and aged rats, with administration of therapy 1 hour post-exposure to simulate real-world scenarios. The study aims to prevent neuronal degeneration, seizures, and behavioral abnormalities.