Award
National Cancer Institute 5P50CA278595-09
Project 2: Predicting Treatment Responses Using Single Cell RNA Sequencing and Bioengineered Patient-derived Organotypic Models of HNC
Recipient
UNIVERSITY OF WISCONSIN-MADISON
Award Amount
$375,726.00
Ceiling
$375,726.00
Awarded
August 12, 2025
Identifier
5P50CA278595-09
The award supports research to predict treatment responses in head and neck cancer patients using advanced single cell RNA sequencing and bioengineered patient-derived models, aiming to improve personalized treatment strategies and clinical outcomes.
Description
This project aims to develop new tools to stratify head and neck cancer (HNC) patients who are more likely to respond to specific treatments by using single cell CITE-seq of HNC tumors combined with patient-specific bioengineered models. The research includes identifying biomarkers, testing treatments on bioengineered models, and conducting a clinical pilot study to improve clinical decision making and treatment outcomes for HNC patients.