Award
National Institute of Neurological Disorders and Stroke 1R21NS142944-01A1
Mechanisms of Axonopathy in CMT1X
Recipient
University of Illinois at Chicago
Award Amount
$200,413.00
Ceiling
$200,413.00
Awarded
June 05, 2026
Identifier
1R21NS142944-01A1
This award funds research on the mechanisms of axonopathy in CMT1X, a form of Charcot Marie Tooth disease, aiming to identify gene expression changes in spinal motor neurons and Schwann cells and how treatments can preserve axonal function.
Description
Charcot Marie Tooth (CMT) disease is a relatively common group of inherited disorders characterized by peripheral neuropathy with progressive limb weakness and sensory loss. CMT1X is the second most common form of CMT. Although the dysfunctional protein causing CMT1X is expressed in Schwann cells, the earliest dysfunction occurs in the axon, which carries information needed for motor and sensory functions. This project investigates pathways causing axonal dysfunction to identify new targets for treating disability in CMT.