Award
NIH Reporter #5R01CA293188-03
Discovery of small molecules targeting Polycomb repressive complexes 1 and 2
Recipient
University of Southern California, Los Angeles, CA
Award Amount
$451,485.00
Ceiling
$451,485.00
Awarded
July 16, 2026
Identifier
5R01CA293188-03
Research project funded by the National Cancer Institute to discover small molecules targeting PRC1 and PRC2 complexes involved in cancer, aiming to develop new therapeutic strategies.
Description
The project aims to identify small molecules that can specifically inhibit Polycomb Repressive Complex 1 (PRC1). This complex plays a crucial role in chromatin regulation and is involved in various human malignancies, including cancer. While much focus has been on PRC2, this research seeks to explore therapeutic strategies targeting PRC1, especially molecules acting downstream or independently of EZH2’s methyltransferase activity.