Award
National Institute of Allergy and Infectious Diseases 5R01AI173307-04
The novel role of HLA-E restricted CD8 regulatory T cells in kidney allograft rejection
Recipient
Brigham and Women's Hospital, Boston, MA, United States
Award Amount
$662,076.00
Ceiling
$662,076.00
Awarded
June 10, 2026
Identifier
5R01AI173307-04
This NIH-funded project investigates the role of HLA-E restricted CD8 regulatory T cells in preventing kidney transplant rejection, aiming to develop targeted therapies to improve graft survival.
Description
The study focuses on the role of antigen-specific CD8 regulatory T cells, restricted to HLA-E, in controlling kidney transplant rejection. It aims to understand how these cells suppress T follicular helper cells and donor-specific antibody generation, with the goal of developing CD8 Treg-based therapies for kidney transplantation.