Award
NIH Reporter #5R01CA305375-02
Pre-synaptic events in homologous recombination and maintenance of genomic stability
Recipient
Saint Louis University, MO, United States
Award Amount
$504,207.00
Ceiling
$504,207.00
Awarded
August 13, 2026
Identifier
5R01CA305375-02
This NIH-funded project by Saint Louis University studies the molecular mechanisms of DNA repair via homologous recombination, focusing on Rad51, Rad52, and BRCA2 proteins to understand genomic stability and cancer prevention.
Description
The project focuses on DNA repair mechanisms, homologous recombination, and the roles of Rad51, Rad52, BRCA2, and related proteins. The research aims to elucidate molecular processes critical for genomic stability and cancer prevention. It aims to decipher how the junction is recognized via RPA-Rad52-Rad51 interactions, how Rad51 paralogs promote filament formation, and how sorting and stacking are enacted in human BRCA2 using methods including ensemble and single-molecule FRET fluorescence microscopy, structural mass spectrometry, and C-trap analysis to understand DSB repair through homologous recombination.