Award
National Institute on Aging 5R01AG068179-05
Loss of transcriptional homeostasis of genes lacking CpG islands during aging
Recipient
Boston University Medical Campus
Award Amount
$443,757.00
Ceiling
$443,757.00
Awarded
April 18, 2025
Identifier
5R01AG068179-05
NIH grant awarded to Boston University Medical Campus to study the impact of chromatin changes on gene expression during aging and potential interventions.
Description
This NIH grant project investigates how changes in chromatin architecture during aging lead to misregulation of genes lacking CpG islands, contributing to tissue deterioration and age-related degenerative changes. It explores pharmacological inhibition of this gene misexpression to delay degeneration.