Award
National Institute on Aging 5R01AG048923-09
Characterization of ApoE4 Induced Phospholipid Dysregulation in AD Pathogenesis
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$648,233.00
Ceiling
$648,233.00
Awarded
March 27, 2025
Identifier
5R01AG048923-09
Research project funded by the National Institute on Aging to study the role of APOE4 in Alzheimer's Disease pathogenesis, focusing on microglial regulation and neuroinflammation mechanisms.
Description
This project aims to elucidate the molecular mechanisms underlying APOE4's pathogenic effects, focusing on the regulation of microglial function by the APOE-synj1-PIP2 signaling pathway during Alzheimer's Disease development. The study involves in vivo studies of humanized APOE mouse models, ex vivo microglial culture, 3-D co-culture systems of human iPSC-derived brain cells, and validation of findings in human brain samples. Data integration from scRNA-seq and RNA-seq will be used for high-resolution network modeling to identify pathways and molecular signatures associated with APOE4-induced neuroinflammation.