Award
National Institute of Dental and Craniofacial Research 5R00DE029878-05
The role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology
Recipient
STATE UNIVERSITY OF NEW YORK AT BUFFALO
Award Amount
$248,999.00
Ceiling
$248,999.00
Awarded
July 28, 2025
Identifier
5R00DE029878-05
Research project awarded to study the role of ZEB2 in neural crest cell formation and craniofacial pathology, focusing on molecular mechanisms and disease modeling.
Description
The project investigates the role of ZEB2 in human neural crest cell formation, craniofacial differentiation, and Mowat-Wilson Syndrome. It aims to elucidate the molecular mechanisms by which ZEB2 regulates TGFb signaling and neural crest development, using human pluripotent stem cells, patient-derived iPSCs, and organoid models.