Award
National Institute of General Medical Sciences 5R35GM140933-05
ERK-mediated regulation of non-coding RNAs during development and disease
Recipient
University of TX MD ANDERSON CAN CTR
Award Amount
$405,000.00
Ceiling
$405,000.00
Awarded
July 03, 2025
Identifier
5R35GM140933-05
This NIH-funded project studies how RAS/ERK signaling affects small non-coding RNAs during early development, with implications for fertility, birth defects, and cancer biology.
Description
The project investigates the role of RAS/ERK signaling in shaping the small non-coding RNA landscape via phosphorylation of Dicer1, Drosha, and DIS3 to regulate maternal transcriptome and proteome during oocyte-to-embryo transition and embryonic morphogenesis. This research has implications for understanding infertility, birth defects, and mammalian biology, with relevance to cancer biology.