Award
National Institute of Allergy and Infectious Diseases 1P01AI197187-01
Defined microbial community to suppress multiple AMR enteric pathogens
Recipient
Baylor College of Medicine, Houston, TX, United States
Award Amount
$400,000.00
Ceiling
$400,000.00
Awarded
June 16, 2026
Identifier
1P01AI197187-01
The award supports research to develop a defined microbial community to suppress multiple antimicrobial-resistant enteric pathogens, aiming to prevent infections by restoring colonization resistance and using phages for decolonization.
Description
This project aims to develop a defined consortium of 16 strains that can suppress colonization of Clostridiodes difficile, ExPEC, and Klebsiella pneumoniae, and to understand the mechanisms involved, optimize a minimal community (CommOpt), and use it with phages to decolonize enteric pathogens. The project involves metabolomics, transcriptomics, bacterial genetics, and functional microbial physiology/ecology, testing in mouse models, and exploring therapeutic strategies.