Award
Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R01HD104606-05
Transcriptional regulation of mammary gland development
Recipient
Michigan State University
Award Amount
$487,189.00
Ceiling
$487,189.00
Awarded
March 27, 2026
Identifier
5R01HD104606-05
NIH awarded a grant to Michigan State University to study the role of repressor E2F transcription factors in mammary gland development, with a focus on E2F5. The project aims to elucidate genetic mechanisms regulating mammary gland development and function, contributing to understanding breast cancer.
Description
This NIH grant project aims to define the role of transcriptional regulation in mammary gland development and function, focusing on the repressor E2F transcription factors. The study will investigate mammary gland phenotypes associated with knockout of E2F5, identify E2F5 target genes, and analyze single-cell RNA sequencing data to understand genetic mechanisms regulating mammary gland development.