Award
National Institute of Neurological Disorders and Stroke 5R21NS139100-02
Investigating Dysfunction of Neuroimmune-Related Processes in Models of ALS/FTD TDP-43
Recipient
University of Massachusetts Medical School Worcester
Award Amount
$209,375.00
Ceiling
$209,375.00
Awarded
March 31, 2026
Identifier
5R21NS139100-02
A research project funded by NINDS to study immune dysfunction in ALS/FTD models involving TDP-43 mutations, using mouse models and stem cell-derived microglia to understand neuroimmune processes.
Description
This research examines immune dysfunction due to ALS/FTD-linked mutations in TDP-43 in vivo and in vitro. Using a knock-in mouse model of mutant TDP-43, the study conducts neurological and omics analyses following mild concussive TBI. The research aims to probe innate immune pathways, characterize CNS cell types including microglia subtypes, and employ human induced pluripotent stem cell (iPSC) derived microglia models. The outcomes could uncover mechanisms by which TDP-43 mis-expression alters the innate immune landscape in the CNS.