Award
National Institute on Drug Abuse 5R01DA059378-03
Effects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across Development
Recipient
Yale University
Award Amount
$515,107.00
Ceiling
$515,107.00
Awarded
March 30, 2026
Identifier
5R01DA059378-03
Research project funded by NIH/NIDA to study the effects of early-life cannabinoid exposure on brain circuitry and cognitive behavior using mouse models, with implications for clinical guidelines and interventions.
Description
This project aims to investigate the neural mechanisms underlying the effects of early-life cannabinoid exposure, focusing on the medial prefrontal cortex (mPFC). The study involves longitudinal 2-photon imaging in mice to assess network activity, eCB dynamics, and behavioral outcomes across development. The project is funded by NIH/NIDA and is expected to have significant translational impact on clinical guidelines for cannabis use in mothers and interventions for affected children.