Award
National Institute of General Medical Sciences 5R35GM156386-02
Understanding general principles in receptor tyrosine kinase signaling through structural and functional studies
Recipient
UT SOUTHWESTERN MEDICAL CENTER, Dallas, TX, United States
Award Amount
$574,000.00
Ceiling
$574,000.00
Awarded
February 09, 2026
Identifier
5R35GM156386-02
This award funds research to understand the activation and regulation mechanisms of receptor tyrosine kinases (RTKs) through structural and functional studies, aiming to inform therapeutic design for related diseases.
Description
The project aims to explore the structures and functions of ligand-bound full-length receptor tyrosine kinases (RTKs) using cryo-EM, biochemistry, and cell biology. It seeks to understand conformational coupling, signaling specificity, biased signaling, and clustering mechanisms of RTKs. The research will contribute to designing new therapeutics for diseases related to RTK malfunctions.