National Institute of General Medical Sciences 2R35GM138018-06

Molecular regulation of stress sensing and processing in gram-positive and gram-negative bacterial models.

NIH grant awarded to Oklahoma State University Stillwater to study bacterial stress sensing and response mechanisms in Bacillus subtilis and Pseudomonas aeruginosa, aiming to improve antimicrobial therapies.

Description

This project investigates how bacteria sense and respond to environmental and internal cues, focusing on two bacterial species: Bacillus subtilis and Pseudomonas aeruginosa. The research aims to elucidate molecular pathways governing cue sensing and response mechanisms that enhance cell survival and fitness. The study employs bacterial genetics, molecular techniques, fluorescence microscopy, and microfluidic technology to understand stress responses and virulence behaviors, with implications for antimicrobial strategies.

View original record