Award
National Institute of General Medical Sciences 5R35GM152085-03
Understanding and controlling protein energy landscapes by combining simulations and experiments
Recipient
University of Pennsylvania, Philadelphia, PA
Award Amount
$401,648.00
Ceiling
$401,648.00
Awarded
April 27, 2026
Identifier
5R35GM152085-03
This award funds research at the University of Pennsylvania to develop and apply advanced computational and experimental tools to study dynamic protein structures, specifically myosin motors, to improve drug design and understanding of genetic variations affecting motor function.
Description
The project aims to test tools combining atomically-detailed computer simulations, biophysical experiments, and machine learning to understand and control protein energy landscapes, focusing on myosin motors important in biology and drug design. The work targets β-cardiac myosin and myosin 1 family to enable more accurate predictions of sequence-function relationships and rational design of new drug-like molecules for controlling motor function, with potential applications in heart disease and parasitic infection treatments.