Award
National Institute of Neurological Disorders and Stroke 5R01NS133205-02
Role of a gut microbiota metabolite indole lactate in myelin repair
Recipient
Johns Hopkins University
Award Amount
$498,573.00
Ceiling
$498,573.00
Awarded
May 12, 2026
Identifier
5R01NS133205-02
NIH grant awarded to Johns Hopkins University to study the role of indole lactate, a gut microbiota metabolite, in promoting myelin repair for multiple sclerosis treatment.
Description
This project aims to demonstrate the ability of the metabolite indole lactate (ILA) to promote remyelination in vivo, understand its mechanisms, and evaluate its efficacy in aged models, with relevance to multiple sclerosis treatment.