Award
National Institute of General Medical Sciences 5R35GM127087-09
The Evolution of Gene Regulation and Human Disease
Recipient
University of California, San Francisco
Award Amount
$451,000.00
Ceiling
$451,000.00
Awarded
April 08, 2026
Identifier
5R35GM127087-09
Research project funded by NIGMS to study gene regulation and its impact on human disease using computational biology and machine learning.
Description
The long-term mission of the lab is to model the effects of DNA sequence differences on phenotypes relevant to disease and evolution. The research focuses on genetic variants that modify gene regulation, their role in evolution and disease risk, and developing machine learning methods to predict molecular phenotypes from DNA sequences. The project also involves reconstructing ancient molecular phenotypes, dissecting gene regulatory divergence, and interpreting non-coding mutations in patient genomes.