Award
NIH Reporter #5P01CA163227-12
Functional Interplay Between PARP, AR and DNA Damage
Recipient
Beth Israel Deaconess Medical Center, Boston, MA, United States
Award Amount
$812,190.00
Ceiling
$812,190.00
Awarded
September 16, 2026
Identifier
5P01CA163227-12
Research project funded by the National Cancer Institute to study the interaction between PARP, androgen receptor signaling, and DNA damage in prostate cancer, aiming to improve treatment strategies.
Description
This project investigates the molecular mechanisms underlying prostate cancer treatment resistance and sensitivity, focusing on the roles of PARP enzymes, BRCA genes, and androgen receptor signaling. It aims to elucidate the functional interplay between AR signaling, PARP enzymes, BRCA1/2, and DNA damage to improve treatment strategies.