Award
National Institute of Allergy and Infectious Diseases 5F30AI183563-02
Dynamic reprogramming of macrophage acetyl-CoA metabolism in endotoxin tolerance
Recipient
University of Wisconsin-Madison
Award Amount
$40,585.00
Ceiling
$40,585.00
Awarded
August 25, 2025
Identifier
5F30AI183563-02
Research project funded by the National Institute of Allergy and Infectious Diseases to study macrophage acetyl-CoA metabolism in endotoxin tolerance, targeting therapeutic strategies for sepsis.
Description
This project investigates the role of acetyl-CoA metabolism in endotoxin tolerance in macrophages, aiming to uncover novel metabolic targets for managing critical illnesses such as sepsis. The research involves studying histone and non-histone protein acetylation, metabolic reprogramming, and immune response regulation in cell lines, primary cultures, and murine models.