Award
National Institutes of Health 11454382
The inactive X: discovering sex genes that influence female vulnerability to Alzheimer's disease
Recipient
Massachusetts General Hospital
Award Amount
$993,000.00
Ceiling
$993,000.00
Awarded
January 21, 2026
Identifier
11454382
Research project focused on identifying X-linked genes that contribute to female vulnerability to Alzheimer's disease using advanced genomic and epigenetic methods.
Description
This project aims to investigate the role of X-linked genes that escape inactivation on the second X chromosome in women, as a potential mechanism for female vulnerability to Alzheimer's disease. The study will employ genomic, transcriptomic, and epigenetic techniques, leveraging large cohorts with neuroimaging and sequencing data.