Award
National Institute of Allergy and Infectious Diseases 5R01AI114720-08
Identification of the untranslated sequence elements and virus-host interactions that modulate flavivirus host-specificity
Recipient
Iowa State University, Ames, IA, United States
Award Amount
$374,132.00
Ceiling
$374,132.00
Awarded
April 17, 2026
Identifier
5R01AI114720-08
Research project to identify genetic elements and virus-host interactions that determine flavivirus host specificity, aiding intervention strategies.
Description
This project aims to identify the specific genomic determinants and molecular mechanisms that influence the host ranges of insect-specific and mosquito/vertebrate flaviviruses. The research will dissect the flavivirus genome, focusing on the 5’ and 3’ untranslated regions (UTRs), capsid gene, and interactions with host proteins, to understand the genetic and molecular basis of flavivirus host-specificity.