Award
National Institute of Allergy and Infectious Diseases 5R01AI175149-04
Prostaglandin E2-Dependent Control of a Mast Cell IL-33/ST2 Pathway in Asthma
Recipient
Brigham and Women's Hospital
Award Amount
$859,874.00
Ceiling
$859,874.00
Awarded
April 01, 2026
Identifier
5R01AI175149-04
NIH research grant awarded to Brigham and Women's Hospital to study prostaglandin E2's role in controlling mast cell pathways involved in asthma inflammation, aiming to develop novel therapies.
Description
This project investigates the role of prostaglandin E2 (PGE2) in preventing severe inflammation in asthma by focusing on mast cell regulation of IL-33/ST2 pathways critical in airway inflammation. The study aims to elucidate mechanisms by which mast cells protect lungs from IL-33-induced type 2 inflammation and how PGE2 modulates receptor expression, with potential implications for new therapeutic strategies for asthma and sinus disease.