Award
National Institute of General Medical Sciences 5R35GM126930-09
Molecular Analysis of Kinetochore Function
Recipient
WHITEHEAD INSTITUTE FOR BIOMEDICAL RES
Award Amount
$793,650.00
Ceiling
$793,650.00
Awarded
April 24, 2026
Identifier
5R35GM126930-09
Award for molecular analysis of kinetochore function to study chromosome segregation using genetics, cell biology, and proteomics, funded by NIGMS.
Description
The project involves molecular analysis of kinetochore function related to chromosome segregation. The project aims to generate a molecular model for kinetochore and spindle-associated proteins to ensure high-fidelity chromosome segregation. It will utilize functional genetics, cell biology, proteomics, and biochemical reconstitution approaches, and involves large-scale phenotypic analysis using Cas9-based optical screening. The project focuses on three goals: molecular basis of chromosome segregation, cellular changes during non-dividing states, and large-scale genetic analysis of cell division.