National Institute of Mental Health 1F32MH143408-01

Causal mechanisms of expectation bias in frontal cortex and its role in motivated behaviors

Research project funded by NIMH to study how frontal cortex circuits affect expectation bias and motivated behaviors using neuromodulation in primates, aiming to inform new therapies for neuropsychiatric disorders.

Description

This project examines the causal role of frontal cortical circuits in generating and updating affective expectations using neuromodulatory and high-density recording techniques in non-human primates. It aims to understand how orbitofrontal cortex influences behavior through outcome expectation signals and how these can be modulated with electrical stimulation. The research will elucidate network dynamics between cortical regions during expectation generation, violation detection, and behavioral adjustment, with implications for developing neuromodulatory therapies for neuropsychiatric disorders.

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