Award
National Institute of Allergy and Infectious Diseases 5R21AI183022-02
Characterizing a novel Brucella small RNA critical for cell envelope integrity
Recipient
Virginia Polytechnic Institute and State University
Award Amount
$235,202.00
Ceiling
$235,202.00
Awarded
May 05, 2025
Identifier
5R21AI183022-02
This award funds research to characterize a novel small RNA in Brucella bacteria critical for cell envelope integrity and virulence, aiming to develop new therapies and vaccines against Brucella infections.
Description
The research aims to define a novel small regulatory RNA pathway in Brucella for future therapeutic development. Brucella spp. are bacteria that cause a debilitating, flu-like disease in humans and are considered potential biological weapons. The project focuses on characterizing the biological and regulatory functions of the small RNA Bsr7, investigating its role under stress conditions, exploring its regulation of infectivity-related genes, and developing new therapeutic and vaccine strategies against Brucella.