Award
NIH Office of the Director 5R21OD037751-02
SIV reservoirs dynamics during aging
Recipient
University of Nebraska Medical Center, Omaha, NE, United States
Award Amount
$300,000.00
Ceiling
$300,000.00
Awarded
August 15, 2025
Identifier
5R21OD037751-02
Research project studying the effects of aging on HIV reservoirs in a non-human primate model to inform HIV cure strategies for older populations.
Description
This project aims to understand the impact of aging on HIV reservoirs using an SIV-infected cART-treated non-human primate model. It focuses on changes in DNA methylation, SIV integration sites, and immune cell functionality in young vs. aged rhesus macaques, with samples from PBMC, lymph nodes, rectal tissue, and brain.