Award
NIH Reporter #5R01NS138370-02
Metabolic regulation of Neutrophil Extracellular Traps (NETs) in TBI
Recipient
Henry Ford Health + Michigan State University Health Sciences, East Lansing, MI, United States
Award Amount
$446,477.00
Ceiling
$446,477.00
Awarded
May 11, 2026
Identifier
5R01NS138370-02
The award funds research on the metabolic regulation of neutrophil extracellular traps in traumatic brain injury, focusing on AMPK activation as a therapeutic target to reduce inflammation and improve outcomes.
Description
This project investigates how AMPK activation influences metabolism and inflammation in traumatic brain injury (TBI). It explores the therapeutic potential of AMPK activators like A-769662 using genetically modified mouse models to identify optimal treatment parameters. The study aims to understand the role of AMPK in reducing NETs formation and inflammation, potentially leading to new therapies for TBI.