Award
National Institute of General Medical Sciences 1R15GM164971-01
Optimization of Therapeutic Protein PEGylation by Integrating Coarse-grain Simulation and Cell-free Protein Synthesis
Recipient
Brigham Young University
Award Amount
$558,383.00
Ceiling
$558,383.00
Awarded
June 30, 2026
Identifier
1R15GM164971-01
This award funds research to optimize therapeutic protein PEGylation using computational and experimental methods to improve drug stability and efficacy.
Description
The project aims to optimize protein PEGylation to develop next-generation therapeutics with improved stability, activity, and retention. It involves computational simulations combined with rapid cell-free protein synthesis to enable site-specific PEGylation, validated on therapeutics like Onconase and Crisantaspase.